Adverse Side Effects of Alzheimer’s Drugs

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It is proved scientifically that there are potentially adverse side effects of Alzheimer’s disease drug. This has been proved through the clinical trials, as per the novel Northwestern Medicine research. A study was conducted on mice and it suggested that the drugs acted like bad electricians and caused the neurons to be mis-wired and intrusive with their ability to communicate messages to the brain. The results from the scientist, whose initial study led to the drug progress, are printed in the periodical Molecular Neuro-degeneration and they are expected to be presented at the annual meeting of AAAS in Vancouver.

The researchers said that they should proceed with caution and keep their eyes open for the probable side effects of these drugs. They feared that these drugs had the capability to impair memory. The drugs are designed to obstruct an enzyme BACE 1. This enzyme promotes the development of the plaque clumps which are a hallmark of the disease Alzheimer’s. Acting as molecular scissors, this enzyme cuts up and releases the proteins which form the plaques. Thus the developers of drugs believed that blocking this enzyme will slow the disease. The researchers further found that BACE1 has a complicated role as brain’s electrician. In that particular role, the enzyme maps out the positions of axons, the wires which associate the neurons to our brain and the entire nervous system.

This entire process is called the axonal guidance. They worked with mice from which the BACE1 was removed genetically. The researchers then found the olfactory system of mice and they noticed that the axons of this system were not wired accurately to the olfactory bulb of the brain. These results prove the main role of BACE1 in the axonal guidance. The researchers say that understanding the general working of BACE1 might help them prevent adverse side effects of the drug.


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