Anti-hypertensive Drugs Decrease Risk For Stroke

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Hypertension has always been a compelling problem for many of the world’s population. This can also lead to other serious diseases, like stroke. As early as possible, it is already important to take preventive measures against it. The research, published in Stroke: Journal of the American Heart Association, revealed that people who are in the pre-hypertensive classification had lower susceptibility to stroke when they administered blood pressure-lowering medications.

In the United States, more than 50 million of adults have pre-hypertension, a blood pressure of 120/80 mm Hg to 139/89 mm Hg. On the other hand, hypertension ranges from 140 mm Hg and higher.

According to Ilke Sipahi, M.D., lead author of the study and associate director of Heart Failure and Transplantation at the Harrington-McLaughlin Heart and Vascular Institute in Cleveland, Ohio, the investigation revolves on adults who have pre-hypertensive levels of blood pressure and presents that administration of blood pressure medicines can modify the stroke risk related with the high-normal readings (top number 120-140).

The study team utilized a meta-analysis of 16 researches. Furthermore, they conducted a data examination comparing anti-hypertensive medicines versus placebo in 70, 664 people who have an average baseline blood pressure levels in the pre-hypertensive range. They discovered the following findings. (1)  Patients who self-administer anti-hypertensive drugs had 22% reduced risk of stroke, in contrast with those who took placebo. All classes of anti-hypertensive medications in the study have similar outcome. (2) No remarkable decline in the heart attack risk was observed, although there had been a trend directed to decreased cardiovascular death in those who took anti-hypertensive medicines. (3) For the reason of avoiding stroke in the study population, 169 participants were treated with anti-hypertensive drugs for an average of 4.3 years.

The American Heart Association guidelines still emphasized lifestyle modifications, instead of medications, in lowering blood pressure in pre-hypertensive people. They are encouraged to include lifestyle changes like weight loss, exercise, nutritious diet( and low salt, low fat diet), and cutting down alcohol consumption (only a maximum of 2 drinks per day for men and 1 drink for women).

However, AHA also adheres to the fact that clear-cut reduction in stroke risk with anti-hypertensive drug regimen is essential, which can complement with lifestyle modifications. Moreover, the cost associated with long-term blood pressure-lowering therapy and related risks should be further looked into, before they can make changes in the guidelines.




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