Diabetes Linked To Body Receptors, Says Recent Genetic Study

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A study which got published in the Journal Nature Genetics discovered a novel confirmation for association between the type 2 diabetes and the body clock hormone melatonin. The study shows that the individuals, who hold exceptional hereditary mutations in the receptor for body clock hormone melatonin, have elevated danger of type 2 diabetes. These conclusions should assist the scientists to precisely analyze individual diabetes risk and could also help towards the progress of personalized treatments. Studies prove that individuals who work at night shifts have an elevated risk of type 2 diabetes as well as heart disease.

According to NIDDK, “among U.S. residents ages 65 years and older, 10.9 million, or 26.9 percent, had diabetes in 2010. About 215,000 people younger than 20 years had diabetes—type 1 or type 2—in the United States in 2010. About 1.9 million people ages 20 years or older were newly diagnosed with diabetes in 2010 in the United States. Diabetes is the leading cause of kidney failure, nontraumatic lower-limb amputations, and new cases of blindness among adults in the United States.”

These studies show that if the individuals opt for disrupted sleep for three days regularly, they will temporarily develop indication of diabetes. The sleep wake cycle of body is authorized by the hormone melatonin. The symptoms include drowsiness and lower body temperature. In a study conducted by the Imperial College London, it was found that an individual with general dissimilarity in the gene for MT2, which is a receptor for melatonin, has greater probability of developing type 2 diabetes. The discharge of insulin, which also controls the level of blood sugar, is known to be controlled by melatonin. The scientists recommend that mutations in the gene MT2 can disrupt the association between the insulin release and the body clock, thereby resulting in abnormal blood sugar control.

They further put forward that blood sugar regulation is one amongst the many processes which regulate the biological clock of the body. This demonstrates how the gene carrying the blue print for principal component in the clock can have a significant impact on the individual’s risk of diabetes. An experiment scrutinized the MT2 gene in 7632 individuals to study the unusual variants which have bigger effect on risk of disease. Their findings conclude that nearly 40 variants were associated with type 2 diabetes of which four were rare and made the receptor incapable of reacting to melatonin. Each mutation was scrutinized by testing what impact they have on the receptor MT2 in human cells. The mutations which absolutely prevented the receptor from functioning proved to have a great impact on diabetes risk, thereby recommending that there is direct association between the receptor MT2 and the diabetes.




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