Endocrine disorders and joint diseases

Recommend to others!

1. Overview

Rheumatic diseases often occur when a person suffer from endocrine disorders (affecting connective tissue cells), because hormones are involved in the development and functioning of connective tissue.

If specific components of connective tissue are altered by abnormal hormonal processes, there will be changes in the physical properties of connective tissue and in the functional capacity of the tissue. So, due to this phenomenon, some rheumatic diseases are triggered.


1. Overview
2. Pituitary gland
3. Thyroid gland
4. Pancreas

2. Pituitary gland

Excessive production of growth hormone leads to excessive growth of children (resulting in gigantism) or acromegaly. Arthritis seen in acromegaly is a distinct type of degenerative joint disease that causes large joint degeneration associated with bone proliferation and frequent back pain.

Excessive mobility of the joints is found until advanced stages of the disease. Joints increasing is caused by fluid collection but also connective tissue proliferation. Overgrowth occurs mainly in knots.

Beside all these, postural deformities can occur consisting of curved spine, curved legs and joints loose. Changes occur in the skull, spine, hands and also in other joints. Excessive prominent heel is another important sign.

Growth hormone contributes to the production of a significant number of cells that cause overgrowth of cartilage and curvature of cartilage, which leads to their degeneration and the overgrowth of bones near the joints.

3. Thyroid gland

Rheumatic conditions associated with thyroid dysfunctions are:

- Arthritis triggered by hypothyroidism – is caused by excess deposits of certain proteins in connective tissue. Thyroid stimulating hormone produced by the pituitary gland in the brain can cause excessive collection of proteins.

Symptoms include vague discomfort and pain, but usually no manifestations of inflammatory processes. Joint thickening and fluid collections occur in 33% of patients. In this case, are involved the knees, ankles, small joints of the hands and feet, which are unusually thick.

- Muscle diseases caused by hypothyroidism – are characterized by symptoms such as slow motion and delayed muscle contractions, fatigue, muscle cramps, muscle pain and stiffness. Muscle enlargement was observed in 15% of patients but muscle contraction is quite rare. Symptoms are aggravated by cold and inactivity.

- Nerve damage due to hypothyroidism – the most common symptoms are numbness or tingling. Carpal tunnel syndrome occurs in 5-10% of patients with hypothyroidism. Specific manifestations are numbness of the thumb, index and middle finger.

-Hyperthyroidism – Thyroid acropachy is an unusual condition that is triggered after treatment for Graves’ disease, a type of hyperactivity of the thyroid gland, found in a low percentage of patients with overactive thyroid. Symptoms consist of rounded toes and toenails, and their inflammation and swelling of the distal extremity soft tissue.

- Bursitis in hyperthyroidism – Bursitis, especially located at the shoulder is associated with overactivity of the thyroid gland. It can also affect other joints of the body. Joints are thickened, soft tissues are inflamed and joint movements will be limited. Often, symptoms improve after specific treatment of overactive thyroid.

- Diseases of the muscles in hyperthyroidism – These types of diseases have several forms in hyperthyroidism. Diffuse muscle diseases are often associated with an overactive thyroid gland. These causes, in a frequency-thigh muscle weakness, which can be mild or severe.

Other symptoms are muscle contraction in muscle and fat collection. Most chemicals within the blood are normal. Eye muscle paralysis can occur. Other less common manifestations are swelling of the eyelids and eye layers, but also eye and nerve inflammation.

- Osteoporosis – The condition can occur in people who suffer from thyroid disorders due to loss of calcium and phosphorus in the body.

- Hashimoto thyroiditis – This condition is an autoimmune process affecting the thyroid gland. Half of patients suffering early thyroid overactivity, manifested at some point hypoactivity of the thyroid gland.

4. Pancreas

Rheumatic conditions associated with the pancreas include:

- DISH – A severe form of arthritis of the spine that cause wear and tearing it, which is called diffuse idiopathic skeletal hyperostosis occurs in approximately 13% of diabetics. Symptoms are usually minor, but most include spine. The radiography will reveal an exaggerated bone proliferation.

- Charcot diabetic arthritis – This is the destructive form of arthritis that occurs in diabetes. The condition affects the feet, ankles, knees and spine. Typical symptoms are minor fractures, decreased blood flow and infection. Thus, damage of the foot structure can occur, but also gait impairment and susceptibility to ulcers and calluses.

- Syndromes resulting from soft tissue contracture – Dupuytren contracture occurs in 15% of diabetics. Wrist stiffness was described in up to 40% of patients with juvenile diabetes. This condition involves the deformity of fingers and joints (especially the fingers 4 and 5) as a result of the contracture.

- Other types of arthritis seen in patients diagnosed with diabetes – Approximately 15% of diabetics develop calcium deposits in joint cartilage, which is scar tissue. There are also questionable relationship between diabetes and gout. Perhaps they are the link between obesity and high cholesterol.

Primary generalized osteoarthritis is more common in diabetics. Also, the bursitis located on the shoulder especially with bilateral involvement is common in patients with diabetes, especially insulin-dependent people and women.



Speak Your Mind


Current day month ye@r *