Enhancing Marijuana-Like Natural Pain Killer in the Body

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Having pain as a subjective feeling is very essential in dealing with patients not just because it disrupts the ability to function of someone but also, it causes some change in the behavioral responses. It is indeed unavoidable to feel physical pain from time to time. Medically, pain is being treated by so many drugs available at the market; others are over-the-counter while some needs doctor’s prescription. Nevertheless, like nearly all drugs, pain medications have untoward side effects (like Morphine Sulfate that is being used in severe pain that can cause respiratory depression).Hence, further studies are being conducted to improve the pain treatment regimen in patients suffering from which.

Human body has several natural pain killers that helps ease stressors and bring backs balance. These natural pain killers that the body has are the chemicals found at the end of every nerve endings called neurotransmitters. It includes serotonin and endorphins that blocks pain sensation. However, these neurotransmitters are individualizing in terms of the body’s production and in some conditions, it is not enough to counteract the pain, resulting in the use of synthetic pain killers.

In recent time, researchers have unleashed a way to strengthen the body’s natural pain antagonists. They proposed that anandamine, one of the natural pain killers in the body, can be enhanced its effectivity by blocking the transport medium of anadamine to enter the cells. This transport medium is known to be called as FLAT (FAAH-like anandamide transporters). The team of researchers led by Daniele Piomelli, UCI’s Louise Turner Arnold Chair in the Neurosciences, explains that anadamine having the same pain killer property like those that are found in marijuana (cannabis), can be a guide in potentiating new pain medication that are far from being addictive and sedative unlike the drugs that are currently at the stores. They also added that by blocking FLAT, it leads to inhibition of the enzyme fatty acid amide hydrolase (FAAH), to breakdown anandamine making the anandamine level higher without causing any effects like marijuana.  Furthermore, by blocking FLAT, the researchers are speculating to give relief to certain kinds of pain as well as limiting the effects of addictive drugs without compromising the pain killing property of the drug.

The study was sustained with the aid of the U.S. National Institute on Drug Abuse, the U.S. National Institute on Alcohol Abuse & Alcoholism, and the U.S. National Institute of General Medical Sciences and researchers from UCI, Italy’s University of Parma and University of Bologna, and the Italian Institute of Technology take part to it.




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