Frequent Stress Affects Memory

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Chronic stress can result in a high toll on the capability to think and emotions in those individuals who have never been subjected to stress. Recently, a team of researchers uncovered a neural mechanism which directly associates frequent stress with affected memory. The research got printed by the Cell press in their March issue of the periodical Neuron and also presents critical insights into why depression responses can activate for many intellectual illnesses. Depression hormones are considered to affect the prefrontal cortex, which is a brain part regulating high level executive mechanisms like functioning memory and judgment making. Earlier work has proved that chronic stress damages PFC – mediated behaviors such as attention and mental flexibility.

But, even now, little is recognized about the molecular targets and intellectual consequences of long period stress in PFC, particularly at times of teenager period when the brain is much emotional to stressors, concludes the main author of the research, Dr. Zhen Yan.

The impact of frequent stress:

The author along with other researchers analyzed if the recurring stress had any negative impact on the glutamate receptors in immature rats. This element signals and plays a significant role in the PFC mechanism. They discovered that in reaction to frequent stress, there was an imperative loss of glutamate receptors, which led to a loss of PFC, mediated cognitive procedures.

The investigators carried on to ascertain the molecular functioning which associated stress with reduction in glutamate receptors and displayed if they obstructed these methods, the stress provoked reduction in dual recognition memory and glutamate receptors can be avoided.

If we take the results together, we will find that a loss of glutamate receptors is an imperative aim of frequent stress and associates chronic stress with irregular PFC mechanism, concludes Dr. Yan.



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