Immune Response of the Body against Cancer

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Every year, there are reported cases of individuals who are diagnosed of having cancer. And, although there were already studies which focused its attention on the major risk factors that can be contributory to the initiation of the over growth of cells which results to the malignancy known as cancer, still the reason behind the development of cancer is left unknown up to this date. Hence, many researchers and experts are continuing to conduct further studies in order to have a deeper understanding about the disease. Also, researchers are now focused on newer treatment modalities which can be used in order to cure disease in the most convenient, cost-effective, and efficient way.

In fact, a new research founds the mechanism behind the immune response against cancer which actually paved way for new opportunities of finding a way in discovering new treatment option for cancer.

According to the study, the immune system is composed of several components which have vital functions in order for the immune system to work efficiently. This is especially important among T lymphocytes in order for the immune system not to over do its work which results to the appearance of autoimmune diseases in which the body’s own immune system attacks the body itself. And regulatory T cells have a very important function in suppressing down the immune response whenever it is not already needed.

Researchers found out an important role of regulatory T cells or also known as “Tregs” in the immune response of the body against cancer. It was noted by the researchers that the regulatory T cells which works by suppressing down the functions of other immune cells can also suppress the body’s response against cancer cells. Hence, researchers at the German Cancer Research Center (DKFZ) tackled that finding a way in order to activate the mechanisms which are blocked by regulatory T cells can actually help the immune system of the body respond to the growing cancer cells.

Moreover, according to Prof. Peter Krammer of DKFZ, he said: “the mode of action of Tregs is of great importance for cancer medicine. Many of our colleagues have shown in various types of cancer that Tregs can downregulate the immune response against tumors so that transformed cells escape the immune defense. This can contribute to the development and spread of cancer. We are therefore searching for ways to reactivate such suppressed helper cells.”





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