Initial Genetic Link to widespread migraine uncovered

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World health organization has defined migraine as that headache disorder where inflammatory chemical that produces pain gets released around the blood vessels and nerves in the head. Migraine generally initiates in puberty and tends to influence individuals aged amid 35 to 45 years of age. Individuals with migraine generally have an attack once in a month, but the frequency of attack can also range amid once a year and once a week. Migraine attacks are most likely shorter in duration and feature nausea in children. An initial genetic risk factor which is connected with general types of migraines has been acknowledged by a world-wide collaboration of researchers.

The researchers studied genetic data of 50,000 people and produced novel insights into the cause of migraine attacks. These researchers hope that their research will unlock the door for new therapeutics which will put a stop to migraine attacks. A team of researchers have found that a patient who has a unique DNA variant on Chromosomes 8 amid the two genes of PGCP and MTDH/AEG-1are at greater threat for developing migraine attacks. This is because the concerned DNA variant regulates the level of glutamate. This chemical transports message amid the nerve cells in the brain. The accumulation of glutamate chemical in the nerve cells junctions in the brain results in the initiation of migraine attack.  To ease the burden of disease, it is necessary to prevent the buildup of the glutamate chemical at the synapse. This will prove to be a promising target for novel therapeutics.

According to the National Institute of Neurological Disorders and Stroke, “many things can trigger a migraine.”

These include:

  • Anxiety
  • Stress
  • Lack of food or sleep
  • Exposure to light
  • Hormonal changes (in women)

“Doctors used to believe migraines were linked to the opening and narrowing of blood vessels in the head. Now they believe the cause is related to genes that control the activity of some brain cells. Medicines can help prevent migraine attacks or help relieve symptoms of attacks when they happen. For many people, treatments to relieve stress can also help,” they further added.

One in twelve men and one in six women are diagnosed with migraine attack. In the society of US and EU, migraine has been estimated to be the most costly disorder of brain. Collaboration amid 40 centres from all around the world has been set up. This collaboration has been steered by International Headache Genetics Consortium to conduct more research work and produce findings to help people get relieve from migraine pain.



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