Leukemia Cells Toxic To Bones

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Researchers from the University of Rochester Medical Centre have now found new connections between the leukemia cells and the cells which are involved in the formation of bones. This study has offered a fresh approach to how the blood cancer progresses and raises the probability that therapies for the bone disorders can help in curing the ailment leukemia. A graduate student led the research in the medical laboratory of Wilmot Cancer Centre which got published in the journal Blood. It was also accompanied by an article “Bad to the Bone”, which was written by one of the leading investigators in the same field. The researchers engaged in the research admit that URMC’s unexpected laboratory results provoked varieties of clinical questions like, “Can the screening for osteoporosis provide any imperative information for how to manage the acute leukemia in novel diagnosed patients”?

Leukemia is one of a devastating disease which leads to the disruption of normal blood production. When this ailment leukemia becomes barely traceable in the blood, leukemia cell implants in the bone marrow and impacts the normal course of action of the body in which it makes the healthy blood stem cells. Researchers focused on the effect of leukemia cells that can be found on the inner lining of the bones which are adjacent to the bone marrow activity. Till date no one has defined the significant interactions that take place between the leukemia cells and the cells that help in bone formation and break down of the bone. The manner is very complex and counterintuitive in which leukemia cells change the cycles and balance of osteoblast and osteoclast activity. This results in various measurable changes in the skeleton.

It is found that leukemia causes widespread and low level bone thinning along with bone loss, especially in long bones. Leukemia results in formation of a protein CCL3, which further slows down the formation of bones. The researchers put forward that the findings are quiet proactive and also hope that they will result to novel approaches in promoting the normal blood production in patients with blood cancers. This study was provided by the University of Rochester Medical Center.

As per the Leukemia and Lymphoma Society, “leukemia is a type of cancer that affects the blood and bone marrow, the spongy center of bones where our blood cells are formed. The disease develops when blood cells produced in the bone marrow grow out of control. About 43,050 people are expected to develop leukemia in 2010.”



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