Mechanism Behind Aging Revealed by Identical Twins

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A recent study which was led by researchers of Uppsala University, evaluate the DNA of identical twins who were of different ages. The findings showed that DNA’s structural modifications, where the small and large DNA segments alter directions, are duplicated or absolutely lost. This is most common in the individuals of older age. The findings are best to give reasons for why the immune system gradually damages with age. Persistent changes occur in the cells’ DNA during the entire life of an individual. The changes can be alterations to the person’s building blocks of DNA. The most common is the rearrangement where the large segment of DNA alters the place or direction, or they are duplicated or absolutely lost.

In a recent study by the researchers the healthy blood cells from the indistinguishable twins of different age were analyzed and scrutinized for the smaller and larger DNA rearrangements. The findings demonstrated that large rearrangements were found only amongst the individuals with age group of 60 years. The most general rearrangement was that the region of DNA for instances an area of chromosome that had been misplaced in some of the human blood cells. Similar rearrangements were located in many other individuals and many of these were correlated with a disease of blood. This disease disturbed that capacity of the bone marrow to produce new blood cells.

These rearrangements were also found in the individuals of younger age but the alterations were smaller and little complex. However the researchers proved that even in this case the age correlated with the number of rearrangements. They were astonished to discover that as many as 3.5% of healthy and fit individuals who were older than 60 years carried such large and complex changes. The research is collaboration amid the researchers of Hudson Alpha Institute and Uppsala University.

According to, “the aging process in biology is defined, in the Free Encyclopedia, as “cumulative changes in an organism, organ, tissue or cell leading to a decrease in functional capacity. In humans, aging is associated with degenerative changes in the skin, bones, heart, blood vessels, lungs, nerves, and other organs and tissues.”




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