New Genetic Treatment for Body Weight Regulation

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An assistant professor in the University of Rhode Island’s College of Pharmacy, Abraham Kovoor, came across the genes which may help to regulate the weight of your body, while he was researching on the affect of RGS9-2, a protein found in human brain which was earlier linked with the movement of our body in a cyclical, reflexive and haphazard manner, on the side effects of drugs used for curing the diseases of schizophrenia and Parkinson. These discovered facts were published in a scientific and medical journal, PLoS One, in its November edition.

Human being with variable genes which can decrease the quantity of RGS9-2 proteins in his brain may come under the index of heavy weight people, according to Kovoor and his associates. They had done a similar experiment on the brain of a mouse by removing RSG9-2 proteins from there and found that the mice attained a heavy weight body with higher ratio of fats, much larger than its wild species. On the other hand, the mouse showed respective affect of loosing weight when an additional quantity of RSG9-2 protein was added to it, with the passage of time.

Kovoor and his associates reached to a decision that this reaction of RSG9-2 protein is due to its presence in the striatum of the brain which controls the mobility of the body as well as rewards the reactions to the body and that is why the weight is gained as a resultant of increased rewards to the diet.

“You would expect more eating from the mice without RGS9-2 (because they were the ones that gained weight), but that was not the case,” Kovoor said. “Studies with humans, rats and mice implicate RGS9-2 as a factor in regulating body weight. But we had to look at another factor other than feeding behavior.”

“Our research shows that the striatum, through RGS9-2, has a role in regulating body weight that is independent of the motivation, movement and reward responses,” Kovoor said. “We have identified a new gene that likely regulates weight gain through metabolism.”

Kovoor and his associates were surprised on their invention of RSG9-2 protein’s additional affect on the weight regulation of the body, which they were studying for reducing the side effects of the drugs used for decades for curing schizophrenia and Parkinson’s disease.

Thus, an invention of genes that regulates the quantity of RSG9-2 proteins in the brain affects directly to the body weight accordingly.




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