A study led by an Assistant Professor Wanguo Liu, at LSU Centre of Health Science of New Orleans, discovered a novel protein which is critical for the growth and development of prostate cancer. The results of the research are available online in the latest edition of a journal “Proceedings of the National Institute of Science”. Dr. Liu along with his team found a protein named ARD1 which is engaged with the male hormone along with its receptor. This cancer is a hormone controlled disease and the principle hormone is androgen. It activates its receptor to perform an important role in the progress and development of the prostate cancer.
Hence the deprivation theory of androgen has been a customary treatment for the latest prostate cancer. Generally most of the tumors habitually decline and develop into an androgen-autonomous prostate cancer due to which most of the patients die eventually, reported by Dr. Liu. To discover an optional strategy to cure prostate cancer, Dr. Liu along with his group is focusing the activators of androgen receptor and growing levels of these activators which lead to prostate cancer. After the identification of this new protein, they are sure that ARD1, is over generated in almost all the samples of prostate cancer. This protein also activates the receptor androgen and is an important constituent of prostate cancer cell enlargement.
Moreover they also proved that inactivation of this protein inhibits the working of the androgen receptor which results in absolute repression of prostate cancer cell enlargement. This particularly occurred in mice where the enlargement was found in tissue culture and prostate tumor. They also proved that the role of protein in the progression of prostate cancer is to adapt the androgen receptor to improve its activity. The researchers say that this study may be of therapeutic benefit in curing the prostate cancer.
The American Cancer Society identified that other than skin cancer, prostate cancer is the most common cancer in American men. The latest American Cancer Society estimates for prostate cancer in the United States are for 2011:
- About 240,890 new cases of prostate cancer will be diagnosed
- About 33,720 men will die of prostate cancer
About 1 man in 6 will be diagnosed with prostate cancer during his lifetime. More than 2 million men in the United States who have been diagnosed with prostate cancer at some point are still alive today.
Prostate cancer is the second leading cause of cancer death in American men, behind only lung cancer. About 1 man in 36 will die of prostate cancer.