New Protein Discover May Lead to HIV Drugs

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A group of researchers from the Educational Institute of Public Health of Johns Hopkins Bloomberg currently discovered a novel protein which can enable HIV to damage the human cells. The conclusions provide the scientists with analytical sight into the complex interactions amid the human proteins and the HIV proteins. This discovery can probably lead to novel drug therapies. The research was printed in the January issue of Journal Nature. HIV is considered to be an efficient pathogen which comprises of 15 proteins that can function in a variety of combinations with approximately 30,000 proteins in a normal human cell.

A human protein APOBEC3G has control to mutate the HIV genome and avoid infectivity. An HIV protein which is mostly called the HIV-1 particularly connects itself and degrades the APOBEC3G to occur. Laying emphasis on the interaction amid the APOBEC3G and Vif, the researchers have discovered another protein which is called the CBF-Beta. This was a principal factor which was required for the degradation of protein APOBEC3G to occur. Xang Fang Yu, a professor admits that he has been studying and functioning in this field for the last 25 years but he is sure that there is still much more to be discovered. He admits that this is an exhilarating time to be in this field for HIV research.

The recognition of CBF- Beta is only sole piece of the mystery, yet it is very significant. In order to deteriorate HIV and the virus, human protein APOBEC3G has been formulated. It has developed a mechanism for overcoming the anti viral factor. Currently there are more than 20 standard anti-viral therapies for HIV and many of them target protein interactions amid the humans and the virus. But with the failure of drugs and appearance of drug-resistance-variants has made it essential to continue the research further and augment the number of HIV drugs. The next step for the scientists is to examine the inhibitors as well as various possible drug therapies. This will help in determining as to which ones disturb the interaction amid CBF-beta and Vif and which ones can put a stop to the degradation of APOBEC3G.

According to the National Institutes of Health, “people who become infected with HIV may have no symptoms for up to 10 years, but they can still pass the infection to others. After being exposed to the virus, it can take up to 3 months for the HIV ELISA blood test to change from HIV negative to HIV positive.HIV has spread throughout the U.S. The disease is more common in urban areas, especially in inner cities.”




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