Ovarian Cancer, May Be Inherited Through the Genes

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A research was conducted by the researchers and colleagues at the Moffitt Cancer Centre in United Kingdom and United States. This research puts forward that inflammation was found to have association with the risk of ovarian cancer. This finding was read in a current issue of journal Cancer Research which is in print by the American Association for the Cancer Research. Several types of cancers are influenced by the chronic inflammation which includes the ovarian cancer also. The researchers discovered nearly 27 genes which are engaged in inflammation and sought to recognize if inter-individual differences in these genes were associated with the risk of ovarian cancer.

In order to perform this they recognized the occurrence of 162 SNIPS in DNA which was extracted from the blood samples. This blood samples were taken from 1000 cancer free women and 900 women diagnosed with ovarian cancer. Whenever a SNP is analyzed it symbolizes that there are 2 kinds of genes and the least general one is called the minor allele. The occurrence of 21 of these 162 SNPs varied amid the controls and cases and was consequently analyzed in a larger research which enclosed 2100 controls and 3100 cases from 5 independent studies.

The researchers evaluated the association amid the SNPs in inflammation which is linked with the genes and the probability of ovarian cancer. They discovered 5 variants from the 27 genes and these were associated with probability of ovarian cancer. The thing which interested them the most was that women who held minor allele were less exposed to the risk of ovarian cancer. Every SNP emerged to lower the probability by nearly 10%. The researchers reported that there were 225,500 new cases of ovarian cancer all across the world in the year 2011. Many of the women are at still at an elevated risk of cancer because of the inherited mutations in genes like BRCA1 and BRAC2. Sellers say that they are looking out for strategies to reduce chronic inflammation.

The National Cancer Institute has identified measures through which a patient can detect an early onset ovarian cancer. “Ovarian cancer usually happens in women over age 50, but it can also affect younger women. Its cause is unknown. Ovarian cancer is hard to detect early.”

Symptoms may include:

  • Heavy feeling in pelvis
  • Pain in lower abdomen
  • Bleeding from the vagina
  • Weight gain or loss
  • Abnormal periods
  • Unexplained back pain that gets worse
  • Gas, nausea, vomiting, or loss of appetite





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