Two Popular Statins at their best –Crestor and Lipitor

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In a world where most of the people are practicing sedentary lifestyle, problems related to it pumps out one by one. Examples include obesity, heart problems, blood vessel ailments and the likes. Due to this, medications are produced to counteract the said problems.

Atheroma or deposition and accumulation of macrophages or fats in the arterial walls are a slow but serious condition that has different remedies. One of which is the use of aggressive treatment with potent statins (drug preparation used to lower down cholesterol level). The use of these statins is helpful in decreasing the build-up of plaque in arteries. Researchers said that commonly used statins, namely rosuvastatin (Crestor) or atorvastatin (Lipitor) both have same desirable effects shown in a study. Stephen J. Nicholls, MBBS, PhD, of the Cleveland Clinic, and colleagues found that the percent atheroma volume (PAV) decreased by 0.99% among patients treated with 80 mg of atorvastatin daily versus an average regression of 1.22% in patients taking 40 mg of rosuvastatin, a statistical dead heat (P=0.10) by the aid of intravascular ultrasound (IVUS) to evaluate atheroma. A secondary efficacy endpoint, normalized total atheroma volume, favored rosuvastatin with a reduction of 6.4 cubic mm versus 4.4 cubic mm in the atorvastatin arm (P=0.01).

During the American Heart Association meeting, the result of the said study was reported accordingly and it was also publish online by The New England Journal of Medicine. The said finding is significantly relevant to clinical practice since atorvastatin will be available as a generic this month, while rosuvastatin is available only as the brand drug Crestor. “Both groups did amazingly well, with more regression than we have ever seen with IVUS,” said Steven E. Nissen, MD, director of cardiovascular medicine at the Cleveland Clinic and a co-investigator of the Study of Coronary Atheroma by Intravascular Ultrasound: Effect of Rosuvastatin versus Atorvastatin (SATURN) trial. “Neither Dr. Nicholls nor I tell doctors what drug to prescribe,” Nissen told MedPage Today. Asked about his own practice, he said that he always “tries in using statins to customize the treatment for each patient, which is why I have plenty of patients on 40 mg simvastatin, which is safe and is a generic, and will have some patients on generic atorvastatin when it becomes available. But for people in whom it is difficult to get LDL down, I use and will use rosuvastatin.” Nissen further commented that atorvastatin “is just a very good drug, there is a reason that it is the only [drug] to reach $10 billion in sales.”



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