Worms[ Microscopic] Are Useful Too: Use them For Badet-Biedl Syndrome

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A new study by a team of researchers from the University of California, San Francisco revealed a new possibility on the genetic disease called Bardet-Biedl Syndrome – a rare condition that occurs in about 1 in 150,000 cases, according to Medical News Today . The finding has been published in the Journal PLoS Biology.

The project is funded and supported by the grants from the Kinship Foundation Searle Scholar’s Award and the Burroughs Welcome Career Award and is also supported by the National Institutes of Health.

Microscopic worms called Cilia – found on the surface of the cells on the human body – allow researches to gain insights on various human functions such as develop of the human body overall, vision, kidney functions, and obesity. The researchers found mutations that cause BBS in these genes that encode a protein complex that is required for Cilia to function properly.

Dr. kaveh Ashrafi of the University of California reports that these organisms provide many similarities to the basic mechanisms in cellular and animal physiology. The mutations match those of the BBS patients most of whom have abnormal eating behaviors, hyper metabolism, small size and sensory defects.

The Bardet-Biedl Syndrome, according to the Foundation Fighting Blindness, is a complex disorder that affects many parts of the body, which includes retina. It involves Retinal Degradation and is similar to retinitis Pigmentosa (RP). It’s usually discovered in childhood when visual problems first start to occur. It can even be found during adolescence and the symptoms only progress rapidly.

The BBS is passed genetically through families with a 25% chance of genetic subscription to the condition. Males with BBS experience possibilities of kidney disease, mental retardation, and tendency to put on weight. The men usually have small genitalia. Women suffering from BBS have irregular menstrual cycles.

Some of the conditions caused by the Syndrome are a short statute, blindness, kidney abnormalities, and obesity. There could also be mild impairment of cognitive capabilities and delayed emotional responses.

The new study could shed new light on this relatively rare condition and help get away from the clutches of this condition, which has multiple negative ramifications for the patients.



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